View source for 3jth


==Crystal structure of a transcriptional regulator HlyU from Vibrio vulnificus CMCP6==
<StructureSection load='3jth' size='340' side='right' caption='[[3jth]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3jth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibvu Vibvu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JTH FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VV1_0512 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216895 VIBVU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jth OCA], [http://pdbe.org/3jth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jth RCSB], [http://www.ebi.ac.uk/pdbsum/3jth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jth ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/3jth_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jth ConSurf].
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== Publication Abstract from PubMed ==
HlyU is a transcription factor of the ArsR/SmtB family and activates the expression of the pathogenic Vibrio vulnificus RTX toxin. In contrast to the other metal-responding ArsR/SmtB proteins, HlyU does not sense metal ions. To provide its structural information, we elucidated the crystal structure of HlyU from V. vulnificus CMCP6 (HlyU_Vv). The monomeric HlyU_Vv architecture of five alpha-helices and two beta-strands, some of which constitute a typical DNA-binding winged helix-turn-helix (wHTH) motif, is very similar to that of other transcription regulators. Nonetheless, the homo-dimeric HlyU_Vv structure shows several different, three-dimensional features in the spatial position and the detailed dimeric interaction, which were not observed in the modeling study based on the same protein family and sequence similarity.

Crystal structure of the transcriptional activator HlyU from Vibrio vulnificus CMCP6.,Nishi K, Lee HJ, Park SY, Bae SJ, Lee SE, Adams PD, Rhee JH, Kim JS FEBS Lett. 2010 Mar 19;584(6):1097-102. Epub 2010 Feb 21. PMID:20178784<ref>PMID:20178784</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3jth" style="background-color:#fffaf0;"></div>

==See Also==
*[[Transcriptional activator|Transcriptional activator]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Vibvu]]
[[Category: Kim, J S]]
[[Category: Lee, H J]]
[[Category: Nishi, K]]
[[Category: Park, S Y]]
[[Category: Dna-binding]]
[[Category: Hlyu]]
[[Category: Rtxa]]
[[Category: Transcription]]
[[Category: Transcription factor]]
[[Category: Transcription regulation]]