View source for 3ltl


==Crystal structure of human BIG1 Sec7 domain==
<StructureSection load='3ltl' size='340' side='right'caption='[[3ltl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ltl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LTL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ltl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltl OCA], [https://pdbe.org/3ltl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ltl RCSB], [https://www.ebi.ac.uk/pdbsum/3ltl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ltl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BIG1_HUMAN BIG1_HUMAN] Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.<ref>PMID:12571360</ref> <ref>PMID:15644318</ref> <ref>PMID:17227842</ref> <ref>PMID:22084092</ref> <ref>PMID:20360857</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Biou V]]
[[Category: Cherfils J]]
[[Category: Joubert A]]
[[Category: Simister PC]]