View source for 3md2


==Crystal structure of the matrix protein 1 from influenza A virus (A/California/04/2009 (H1N1))==
<StructureSection load='3md2' size='340' side='right'caption='[[3md2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3md2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/04/2009(H1N1)) Influenza A virus (A/California/04/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MD2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3md2 OCA], [https://pdbe.org/3md2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3md2 RCSB], [https://www.ebi.ac.uk/pdbsum/3md2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3md2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D3TEK8_9INFA D3TEK8_9INFA] Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.[ARBA:ARBA00025019][HAMAP-Rule:MF_04068][RuleBase:RU362105]  Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.[ARBA:ARBA00024859][HAMAP-Rule:MF_04068][RuleBase:RU362105]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Height J]]
[[Category: Kloss B]]
[[Category: Liu Q]]
[[Category: Love J]]
[[Category: Skowronski ES]]