View source for 3mnn


==A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core==
<StructureSection load='3mnn' size='340' side='right'caption='[[3mnn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3mnn]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MNN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MML:1-METHYL-4-(1-METHYLETHYL)BENZENE'>MML</scene>, <scene name='pdbligand=PTW:1,3,5-TRIAZA-7-PHOSPHATRICYCLO[3.3.1.1~3,7~]DECANE'>PTW</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mnn OCA], [https://pdbe.org/3mnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mnn RCSB], [https://www.ebi.ac.uk/pdbsum/3mnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mnn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

==See Also==
*[[Histone 3D structures|Histone 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Davey CA]]
[[Category: Ong MS]]