View source for 3nfz


==Crystal structure of murine aminoacylase 3 in complex with N-acetyl-L-tyrosine==
<StructureSection load='3nfz' size='340' side='right'caption='[[3nfz]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3nfz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.147&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3NF:N-ACETYL-L-TYROSINE'>3NF</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfz OCA], [https://pdbe.org/3nfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfz RCSB], [https://www.ebi.ac.uk/pdbsum/3nfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACY3_MOUSE ACY3_MOUSE] Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids.<ref>PMID:14656720</ref> <ref>PMID:17012540</ref> 

==See Also==
*[[Aminoacylase 3D structures|Aminoacylase 3D structures]]
*[[Aspartoacylase 3D structures|Aspartoacylase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Abramson J]]
[[Category: Abuladze N]]
[[Category: Hsieh JM]]
[[Category: Kurtz I]]
[[Category: Magilnick N]]
[[Category: Pushkin A]]
[[Category: Sawaya MR]]
[[Category: Tsirulnikov K]]