View source for 3nkf


==Crystal structure of human ligand-free mature caspase-6 with intersubunit linker attached==
<StructureSection load='3nkf' size='340' side='right'caption='[[3nkf]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3nkf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NKF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nkf OCA], [https://pdbe.org/3nkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nkf RCSB], [https://www.ebi.ac.uk/pdbsum/3nkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nkf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

==See Also==
*[[Caspase 3D structures|Caspase 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Hardy JA]]
[[Category: Vaidya S]]