View source for 3nws


==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13==
<StructureSection load='3nws' size='340' side='right'caption='[[3nws]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3nws]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nws OCA], [https://pdbe.org/3nws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nws RCSB], [https://www.ebi.ac.uk/pdbsum/3nws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nws ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Harper S]]
[[Category: Johnson FB]]
[[Category: Mason M]]
[[Category: Mitchell MT]]
[[Category: Skordalakes E]]
[[Category: Smith JS]]
[[Category: Speicher DW]]