View source for 3nzj


==Crystal structure of yeast 20S proteasome in complex with ligand 2a==
<StructureSection load='3nzj' size='340' side='right'caption='[[3nzj]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3nzj]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NZJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABN:BENZYLAMINE'>ABN</scene>, <scene name='pdbligand=BOC:TERT-BUTYL+HYDROGEN+CARBONATE'>BOC</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=TRO:2-HYDROXY-TRYPTOPHAN'>TRO</scene>, <scene name='pdbligand=TY5:O-BENZYL-L-TYROSINE'>TY5</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nzj OCA], [https://pdbe.org/3nzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nzj RCSB], [https://www.ebi.ac.uk/pdbsum/3nzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nzj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

==See Also==
*[[Proteasome 3D structures|Proteasome 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Basse N]]
[[Category: Gallastegui N]]
[[Category: Genin E]]
[[Category: Groll M]]
[[Category: Huber R]]
[[Category: Le Ravalec V]]
[[Category: Marechal X]]
[[Category: Moroder M]]
[[Category: Reboud-Ravaux M]]
[[Category: Richy N]]
[[Category: Vidal V]]