View source for 3oai


==Crystal structure of the extra-cellular domain of human myelin protein zero==
<StructureSection load='3oai' size='340' side='right'caption='[[3oai]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3oai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OAI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oai OCA], [https://pdbe.org/3oai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oai RCSB], [https://www.ebi.ac.uk/pdbsum/3oai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oai ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MYP0_HUMAN MYP0_HUMAN] Palmoplantar keratoderma-hereditary motor and sensory neuropathy syndrome;Autosomal dominant intermediate Charcot-Marie-Tooth disease type D;Autosomal dominant Charcot-Marie-Tooth disease type 2I;Roussy-Levy syndrome;Autosomal dominant intermediate Charcot-Marie-Tooth disease with neuropathic pain;Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease type 1B;Autosomal dominant Charcot-Marie-Tooth disease type 2J. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease may be caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/MYP0_HUMAN MYP0_HUMAN] Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.<ref>PMID:10545037</ref> <ref>PMID:18337304</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Brunzelle J]]
[[Category: Kamholz J]]
[[Category: Kovari IA]]
[[Category: Kovari LC]]
[[Category: Liu Z]]
[[Category: Sohi J]]
[[Category: Wang Y]]