View source for 3otd


==Crystal structure of human tRNAHis guanylyltransferase (Thg1)- NaI derivative==
<StructureSection load='3otd' size='340' side='right'caption='[[3otd]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3otd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OTD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3otd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3otd OCA], [https://pdbe.org/3otd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3otd RCSB], [https://www.ebi.ac.uk/pdbsum/3otd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3otd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THG1_HUMAN THG1_HUMAN] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.<ref>PMID:21059936</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Doublie S]]
[[Category: Eckenroth BE]]
[[Category: Hyde SJ]]