View source for 3owx


==X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values==
<StructureSection load='3owx' size='340' side='right'caption='[[3owx]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3owx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=XRA:2-[4-(FURAN-2-YLCARBONYL)PIPERAZIN-1-YL]-6,7-DIMETHOXYQUINAZOLIN-4-AMINE'>XRA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owx OCA], [https://pdbe.org/3owx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owx RCSB], [https://www.ebi.ac.uk/pdbsum/3owx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> 

==See Also==
*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Boutin JA]]
[[Category: Delagrange P]]
[[Category: Ferry G]]
[[Category: Mesecar AD]]
[[Category: Pegan SD]]
[[Category: Sturdy M]]