View source for 3p49


==Crystal Structure of a Glycine Riboswitch from Fusobacterium nucleatum==
<StructureSection load='3p49' size='340' side='right'caption='[[3p49]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3p49]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusobacterium_nucleatum_subsp._polymorphum Fusobacterium nucleatum subsp. polymorphum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P49 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p49 OCA], [https://pdbe.org/3p49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p49 RCSB], [https://www.ebi.ac.uk/pdbsum/3p49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p49 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref> 

==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
*[[Riboswitch 3D structures|Riboswitch 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Fusobacterium nucleatum subsp. polymorphum]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Butler EB]]
[[Category: Strobel S]]
[[Category: Wang J]]
[[Category: Xiong Y]]