View source for 3phn


==Crystal structure of wild-type onconase with resolution 1.46 A==
<StructureSection load='3phn' size='340' side='right'caption='[[3phn]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3phn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_pipiens Lithobates pipiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3phn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3phn OCA], [https://pdbe.org/3phn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3phn RCSB], [https://www.ebi.ac.uk/pdbsum/3phn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3phn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RNP30_LITPI RNP30_LITPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Lithobates pipiens]]
[[Category: Kurpiewska K]]
[[Category: Lewinski K]]
[[Category: Loch J]]
[[Category: Ribo M]]
[[Category: Torrent G]]
[[Category: Vilanova M]]