View source for 3qhb


==Crystal structure of oxidized Symerythrin from Cyanophora paradoxa==
<StructureSection load='3qhb' size='340' side='right'caption='[[3qhb]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3qhb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyanophora_paradoxa Cyanophora paradoxa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QHB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qhb OCA], [https://pdbe.org/3qhb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qhb RCSB], [https://www.ebi.ac.uk/pdbsum/3qhb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qhb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YCX8_CYAPA YCX8_CYAPA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
All known internal covalent cross-links in proteins involve functionalized groups having oxygen, nitrogen, or sulfur atoms present to facilitate their formation. Here, we report a carbon-carbon cross-link between two unfunctionalized side chains. This valine-phenyalanine cross-link, produced in an oxygen-dependent reaction, is generated by its own carboxylate-bridged diiron center and serves to stabilize the metallocenter. This finding opens the door to new types of posttranslational modifications, and it demonstrates new catalytic potential of diiron centers.

A diiron protein autogenerates a valine-phenylalanine cross-link.,Cooley RB, Rhoads TW, Arp DJ, Karplus PA Science. 2011 May 20;332(6032):929. PMID:21596985<ref>PMID:21596985</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3qhb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cyanophora paradoxa]]
[[Category: Large Structures]]
[[Category: Arp DJ]]
[[Category: Cooley RB]]
[[Category: Karplus PA]]