View source for 3qls


==Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP115A)==
<StructureSection load='3qls' size='340' side='right'caption='[[3qls]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3qls]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.733&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=55V:6-METHYL-5-[3-METHYL-3-(3,4,5-TRIMETHOXYPHENYL)BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE'>55V</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qls OCA], [https://pdbe.org/3qls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qls RCSB], [https://www.ebi.ac.uk/pdbsum/3qls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qls ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_CANAX DYR_CANAX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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</StructureSection>
[[Category: Candida albicans]]
[[Category: Large Structures]]
[[Category: Anderson AC]]
[[Category: Bendel SD]]
[[Category: Paulsen JL]]