View source for 3qmg


==Structural Basis of Selective Binding of Non-Methylated CpG islands by the CXXC Domain of CFP1==
<StructureSection load='3qmg' size='340' side='right'caption='[[3qmg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3qmg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmg OCA], [https://pdbe.org/3qmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmg RCSB], [https://www.ebi.ac.uk/pdbsum/3qmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CXXC1_HUMAN CXXC1_HUMAN] Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.<ref>PMID:21407193</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bian C]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: MacKenzie F]]
[[Category: Min J]]
[[Category: Weigelt J]]
[[Category: Xu C]]