View source for 3qve


==Crystal structure of human HMG box-containing protein 1, HBP1==
<StructureSection load='3qve' size='340' side='right'caption='[[3qve]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3qve]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qve OCA], [https://pdbe.org/3qve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qve RCSB], [https://www.ebi.ac.uk/pdbsum/3qve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qve ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBP1_HUMAN HBP1_HUMAN] Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.<ref>PMID:10958660</ref> <ref>PMID:10562551</ref> <ref>PMID:11500377</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Chaikuad A]]
[[Category: Cocking R]]
[[Category: Edwards AM]]
[[Category: Filippakopoulos P]]
[[Category: Krojer T]]
[[Category: Krysztofinska E]]
[[Category: Oppermann U]]
[[Category: Structural genomic]]
[[Category: Ugochukwu E]]
[[Category: Vollmar M]]
[[Category: Weigelt J]]
[[Category: Yue WW]]
[[Category: Von Delft F]]