View source for 3rbw


==Crystal structure of Spire KIND domain==
<StructureSection load='3rbw' size='340' side='right'caption='[[3rbw]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3rbw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbw OCA], [https://pdbe.org/3rbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rbw RCSB], [https://www.ebi.ac.uk/pdbsum/3rbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rbw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPIR1_HUMAN SPIR1_HUMAN] Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.<ref>PMID:11747823</ref> <ref>PMID:21620703</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Eck MJ]]
[[Category: Kreutz B]]
[[Category: Lu J]]
[[Category: Quinlan ME]]
[[Category: Rodal AA]]
[[Category: Toms AV]]
[[Category: Vizcarra CL]]
[[Category: Zheng W]]