View source for 3rkg


==Structural and Functional Characterization of the Yeast Mg2+ Channel Mrs2==
<StructureSection load='3rkg' size='340' side='right'caption='[[3rkg]], [[Resolution|resolution]] 1.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3rkg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RKG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkg OCA], [https://pdbe.org/3rkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rkg RCSB], [https://www.ebi.ac.uk/pdbsum/3rkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rkg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MRS2_YEAST MRS2_YEAST] High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.<ref>PMID:11544180</ref> <ref>PMID:12628916</ref> <ref>PMID:17827224</ref> <ref>PMID:20653776</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Carugo O]]
[[Category: Djinovic-Carugo K]]
[[Category: Khan MB]]
[[Category: Schweyen RJ]]
[[Category: Sjoeblom B]]
[[Category: Sponder G]]
[[Category: Svidova S]]