View source for 3rs6


==Crystal structure Dioclea virgata lectin in complexed with X-mannose==
<StructureSection load='3rs6' size='340' side='right'caption='[[3rs6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3rs6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dioclea_virgata Dioclea virgata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RS6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rs6 OCA], [https://pdbe.org/3rs6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rs6 RCSB], [https://www.ebi.ac.uk/pdbsum/3rs6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rs6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LECA_DIOVI LECA_DIOVI] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.[REFERENCE:1]<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dioclea virgata]]
[[Category: Large Structures]]
[[Category: Alencar KL]]
[[Category: Bezerra EHS]]
[[Category: Bezerra MJB]]
[[Category: Gadelha CAA]]
[[Category: Nagano CS]]
[[Category: Santi-Gadelha T]]
[[Category: Silva-Filho JC]]