View source for 3rwo


==Crystal structure of YPT32 in complex with GDP==
<StructureSection load='3rwo' size='340' side='right'caption='[[3rwo]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3rwo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RWO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwo OCA], [https://pdbe.org/3rwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rwo RCSB], [https://www.ebi.ac.uk/pdbsum/3rwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YPT32_YEAST YPT32_YEAST] Required for protein transport through the secretory pathway. Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment. Mediates the proper polarized localization of SEC2, a GEF for SEC4, but does not alter the exchange activity of SEC2 on SEC4. Plays a role in autophagy.<ref>PMID:12045183</ref> <ref>PMID:12478387</ref> <ref>PMID:23078654</ref> <ref>PMID:8978673</ref> <ref>PMID:9151665</ref> 

==See Also==
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Dregger C]]
[[Category: Franklin E]]
[[Category: Jin Y]]
[[Category: Khan AR]]
[[Category: Sultana A]]
[[Category: Weisman LS]]