View source for 3s6b


==Crystal structure of methionine aminopeptidase 1b from Plasmodium Falciparum, PF10_0150==
<StructureSection load='3s6b' size='340' side='right'caption='[[3s6b]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3s6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S6B FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s6b OCA], [https://pdbe.org/3s6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s6b RCSB], [https://www.ebi.ac.uk/pdbsum/3s6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s6b ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAP1B_PLAF7 MAP1B_PLAF7] Cotranslationally removes the N-terminal methionine from nascent proteins (PubMed:16983082, PubMed:27023914). The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (By similarity). May play an important role in parasite growth during the blood asexual stage (PubMed:16983082).[HAMAP-Rule:MF_03174]<ref>PMID:16983082</ref> <ref>PMID:27023914</ref> 

==See Also==
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Arrowsmith CH]]
[[Category: Artz JD]]
[[Category: Bountra C]]
[[Category: Crombet L]]
[[Category: Edwards AM]]
[[Category: Hills T]]
[[Category: Hui R]]
[[Category: Lew J]]
[[Category: Tempel W]]
[[Category: Weadge J]]
[[Category: Weigelt J]]
[[Category: Wernimont AK]]