View source for 3sde


==Crystal structure of a paraspeckle-protein heterodimer, PSPC1/NONO==
<StructureSection load='3sde' size='340' side='right'caption='[[3sde]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3sde]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SDE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sde OCA], [https://pdbe.org/3sde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sde RCSB], [https://www.ebi.ac.uk/pdbsum/3sde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sde ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSPC1_HUMAN PSPC1_HUMAN] Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). Together with NONO, required for the formation of nuclear paraspeckles.<ref>PMID:22416126</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bond CS]]
[[Category: Lee M]]
[[Category: Passon DM]]