View source for 3sfi


==Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.==
<StructureSection load='3sfi' size='340' side='right'caption='[[3sfi]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3sfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SFI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SF:5,5,5-TRIFLUORO-1-{4-[3-(1,3-THIAZOL-2-YL)-1,2,4-OXADIAZOL-5-YL]PIPERIDIN-1-YL}PENTAN-1-ONE'>3SF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfi OCA], [https://pdbe.org/3sfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sfi RCSB], [https://www.ebi.ac.uk/pdbsum/3sfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sfi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> 

==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Baulard AR]]
[[Category: Blondiaux N]]
[[Category: Brodin P]]
[[Category: Christophe T]]
[[Category: D prez B]]
[[Category: Desroses M]]
[[Category: Flament MP]]
[[Category: Flipo M]]
[[Category: Jeon HK]]
[[Category: Lecat-Guillet N]]
[[Category: Leroux F]]
[[Category: Locht C]]
[[Category: Mathys V]]
[[Category: Piveteau C]]
[[Category: Siepmann J]]
[[Category: Soror SH]]
[[Category: Villemagne B]]
[[Category: Villeret V]]
[[Category: Willand N]]
[[Category: Wintjens R]]
[[Category: Wohlkonig A]]