View source for 3sh3


==Crystal structure of a pro-inflammatory lectin from the seeds of Dioclea wilsonii STANDL==
<StructureSection load='3sh3' size='340' side='right'caption='[[3sh3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3sh3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macropsychanthus_wilsonii Macropsychanthus wilsonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SH3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3B:D-VINYLGLYCINE'>A3B</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh3 OCA], [https://pdbe.org/3sh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sh3 RCSB], [https://www.ebi.ac.uk/pdbsum/3sh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sh3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LECA_MACWI LECA_MACWI] D-mannose/D-glucose-binding lectin with hemagglutinating activity towards rabbit and human erythrocytes. In rats, elicits an acute inflammatory response by inducing neutrophil migration and induces dose-dependent paw edema.<ref>PMID:21694673</ref> <ref>PMID:21924319</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Macropsychanthus wilsonii]]
[[Category: Assreuy AMS]]
[[Category: Bezerra GA]]
[[Category: Bezerra MJB]]
[[Category: Cavada BS]]
[[Category: Delatorre P]]
[[Category: Gruber K]]
[[Category: Nagano CS]]
[[Category: Nascimento KS]]
[[Category: Rangel TBA]]
[[Category: Rocha BAM]]
[[Category: Sampaio AH]]