View source for 3sua


==Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1==
<StructureSection load='3sua' size='340' side='right'caption='[[3sua]], [[Resolution|resolution]] 4.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3sua]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SUA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sua OCA], [https://pdbe.org/3sua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sua RCSB], [https://www.ebi.ac.uk/pdbsum/3sua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sua ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLXB1_HUMAN PLXB1_HUMAN] Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.<ref>PMID:12198496</ref> <ref>PMID:12196628</ref> <ref>PMID:15210733</ref> <ref>PMID:19843518</ref> <ref>PMID:20877282</ref> <ref>PMID:21912513</ref> 

==See Also==
*[[Plexin 3D structures|Plexin 3D structures]]
*[[Rac 3D structures|Rac 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aricescu AR]]
[[Category: Bell CH]]
[[Category: Jones EY]]
[[Category: Siebold C]]