View source for 3sug


==Crystal structure of NS3/4A protease variant A156T in complex with MK-5172==
<StructureSection load='3sug' size='340' side='right'caption='[[3sug]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3sug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SUG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SUE:(1AR,5S,8S,10R,22AR)-5-TERT-BUTYL-N-{(1R,2S)-1-[(CYCLOPROPYLSULFONYL)CARBAMOYL]-2-ETHENYLCYCLOPROPYL}-14-METHOXY-3,6-DIOXO-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-TETRADECAHYDRO-8H-7,10-METHANOCYCLOPROPA[18,19][1,10,3,6]DIOXADIAZACYCLONONADECINO[11,12-B]QUINOXALINE-8-CARBOXAMIDE'>SUE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sug OCA], [https://pdbe.org/3sug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sug RCSB], [https://www.ebi.ac.uk/pdbsum/3sug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sug ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A8DG50_9HEPC A8DG50_9HEPC] 

==See Also==
*[[Virus protease 3D structures|Virus protease 3D structures]]
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</StructureSection>
[[Category: Hepatitis C virus genotype 1a]]
[[Category: Large Structures]]
[[Category: Romano KP]]
[[Category: Schiffer CA]]