View source for 3syv


==Crystal structure of mPACSIN 3 F-BAR domain mutant==
<StructureSection load='3syv' size='340' side='right'caption='[[3syv]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3syv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SYV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3syv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syv OCA], [https://pdbe.org/3syv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3syv RCSB], [https://www.ebi.ac.uk/pdbsum/3syv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3syv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PACN3_MOUSE PACN3_MOUSE] Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bai X]]