View source for 3tdh


==Structure of the regulatory fragment of sccharomyces cerevisiae AMPK in complex with AMP==
<StructureSection load='3tdh' size='340' side='right'caption='[[3tdh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tdh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TDH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tdh OCA], [https://pdbe.org/3tdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tdh RCSB], [https://www.ebi.ac.uk/pdbsum/3tdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tdh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNF1_YEAST SNF1_YEAST] Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8. Phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, and which is required for transcriptional activation through TBP recruitment to the promoters.<ref>PMID:15719021</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Carling D]]
[[Category: Carmena D]]
[[Category: Gamblin SJ]]
[[Category: Haire LF]]
[[Category: Heath R]]
[[Category: Jing C]]
[[Category: Leiper FC]]
[[Category: Martin SR]]
[[Category: Mayer FV]]
[[Category: McCartney R]]
[[Category: Ogrodowicz R]]
[[Category: Sanders MJ]]
[[Category: Schmidt MC]]
[[Category: Underwood E]]
[[Category: Walker PA]]
[[Category: Xiao B]]