View source for 3tg6


==Crystal Structure of Influenza A Virus nucleoprotein with Ligand==
<StructureSection load='3tg6' size='340' side='right'caption='[[3tg6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tg6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Wilson-Smith/1933(H1N1)) Influenza A virus (A/Wilson-Smith/1933(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TG6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0MM:[4-(2-CHLORO-4-NITROPHENYL)PIPERAZIN-1-YL][3-(2-CHLOROPYRIDIN-3-YL)-5-METHYL-1,2-OXAZOL-4-YL]METHANONE'>0MM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tg6 OCA], [https://pdbe.org/3tg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tg6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tg6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q1K9H2_I33A0 Q1K9H2_I33A0] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).[SAAS:SAAS002141_004_603280]

==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Baldwin ET]]
[[Category: Edavettal S]]
[[Category: Kiefersauer R]]
[[Category: Langley DR]]
[[Category: Lewis HA]]
[[Category: Maskos K]]
[[Category: McDonnell PA]]
[[Category: Mortl M]]
[[Category: Pearce BC]]
[[Category: Steinbacher S]]