View source for 3tq2


==Merohedral twinning in protein crystals revealed a new synthetic three helix bundle motif==
<StructureSection load='3tq2' size='340' side='right'caption='[[3tq2]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tq2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TQ2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tq2 OCA], [https://pdbe.org/3tq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tq2 RCSB], [https://www.ebi.ac.uk/pdbsum/3tq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tq2 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Here, we present the crystal structure of the synthetic peptide KE1, which contains four K-coil heptads separated in the middle by the QFLMLMF heptad. The structure determination reveals the presence of a canonical parallel three stranded coiled coil. The geometric characteristics of this structure are compared with other coiled coils with the same topology. Furthermore, for this topology, the analysis of the propensity of the single amino acid to occupy a specific position in the heptad sequence is reported. A number of viral proteins use specialized coiled coil tail needles to inject their genetic material into the host cells. The simplicity and regularity of the coiled coil arrangement made it an attractive system for de novo design of key molecules in drug delivery systems, vaccines, and therapeutics.

Analysis of the crystal structure of a parallel three-stranded coiled coil.,de March M, Hickey N, Geremia S Proteins. 2023 Sep;91(9):1254-1260. doi: 10.1002/prot.26557. Epub 2023 Jul 27. PMID:37501532<ref>PMID:37501532</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3tq2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: De March M]]
[[Category: Geremia S]]