View source for 3tsi


==Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) stalk domain==
<StructureSection load='3tsi' size='340' side='right'caption='[[3tsi]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tsi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_virus_5_(strain_W3) Simian virus 5 (strain W3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TSI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.651&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsi OCA], [https://pdbe.org/3tsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tsi RCSB], [https://www.ebi.ac.uk/pdbsum/3tsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HN_PIV5 HN_PIV5] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).  Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.

==See Also==
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Bose S]]
[[Category: Jardetzky TS]]
[[Category: Kors CA]]
[[Category: Lamb RA]]
[[Category: Welch BD]]
[[Category: Yuan P]]