View source for 3tt9


==Crystal structure of the stable degradation fragment of human plakophilin 2 isoform a (PKP2a) C752R variant==
<StructureSection load='3tt9' size='340' side='right'caption='[[3tt9]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tt9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TT9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tt9 OCA], [https://pdbe.org/3tt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tt9 RCSB], [https://www.ebi.ac.uk/pdbsum/3tt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tt9 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PKP2_HUMAN PKP2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/PKP2_HUMAN PKP2_HUMAN] May play a role in junctional plaques.<ref>PMID:22781308</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gerull B]]
[[Category: Heinemann U]]
[[Category: Roske Y]]
[[Category: Schuetz A]]