View source for 3uby


==Crystal structure of human alklyadenine DNA glycosylase in a lower and higher-affinity complex with DNA==
<StructureSection load='3uby' size='340' side='right'caption='[[3uby]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UBY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDC:N3,N4-ETHENO-2-DEOXYCYTIDINE-5-MONOPHOSPHATE'>EDC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uby OCA], [https://pdbe.org/3uby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uby RCSB], [https://www.ebi.ac.uk/pdbsum/3uby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uby ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/3MG_HUMAN 3MG_HUMAN] Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

==See Also==
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Davis CA]]
[[Category: Drennan CL]]
[[Category: Lingaraju GM]]
[[Category: Samson LD]]
[[Category: Setser JW]]