View source for 3ukr


==Crystal structure of Bos taurus Arp2/3 complex with bound inhibitor CK-666==
<StructureSection load='3ukr' size='340' side='right'caption='[[3ukr]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ukr]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UKR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CKH:2-FLUORO-N-[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]BENZAMIDE'>CKH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ukr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ukr OCA], [https://pdbe.org/3ukr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ukr RCSB], [https://www.ebi.ac.uk/pdbsum/3ukr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ukr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARP3_BOVIN ARP3_BOVIN] Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity).

==See Also==
*[[Actin-related protein 3D structures|Actin-related protein 3D structures]]
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Han M]]
[[Category: Nolen BJ]]