View source for 3uku


==Structure of Arp2/3 complex with bound inhibitor CK-869==
<StructureSection load='3uku' size='340' side='right'caption='[[3uku]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uku]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UKU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C69:(2S)-2-(3-BROMOPHENYL)-3-(2,4-DIMETHOXYPHENYL)-1,3-THIAZOLIDIN-4-ONE'>C69</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uku OCA], [https://pdbe.org/3uku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uku RCSB], [https://www.ebi.ac.uk/pdbsum/3uku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uku ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARP3_BOVIN ARP3_BOVIN] Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity).

==See Also==
*[[Actin-related protein 3D structures|Actin-related protein 3D structures]]
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Han M]]
[[Category: Nolen BJ]]