View source for 3uqw


==Crystal structure of BACE1 with its inhibitor==
<StructureSection load='3uqw' size='340' side='right'caption='[[3uqw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uqw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UQW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZPY:ETHYL+1-{(2S,3S)-3-[(3-{[(1R)-1-(4-FLUOROPHENYL)ETHYL]CARBAMOYL}-5-[METHYL(METHYLSULFONYL)AMINO]BENZOYL)AMINO]-2-HYDROXY-4-PHENYLBUTYL}-1H-PYRAZOLE-4-CARBOXYLATE'>ZPY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uqw OCA], [https://pdbe.org/3uqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uqw RCSB], [https://www.ebi.ac.uk/pdbsum/3uqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uqw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> 

==See Also==
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen TT]]
[[Category: Chen WY]]
[[Category: Xu YC]]