View source for 3ur4


==Crystal structure of human WD repeat domain 5 with compound==
<StructureSection load='3ur4' size='340' side='right'caption='[[3ur4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ur4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UR4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0BW:METHYL+3-[(3-METHOXYBENZOYL)AMINO]-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE'>0BW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ur4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ur4 OCA], [https://pdbe.org/3ur4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ur4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ur4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ur4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> 

==See Also==
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Al-Awar R]]
[[Category: Allali Hassani A]]
[[Category: Arrowsmith CH]]
[[Category: Bolshan Y]]
[[Category: Bountra C]]
[[Category: Brown P]]
[[Category: Chau I]]
[[Category: Dombrovski L]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: Hajian T]]
[[Category: Nguyen KT]]
[[Category: Poda G]]
[[Category: Schapira M]]
[[Category: Senisterra G]]
[[Category: Smil D]]
[[Category: Vedadi M]]
[[Category: Wasney GA]]
[[Category: Weigelt J]]
[[Category: Wernimont A]]
[[Category: Wu H]]