View source for 3uwo


==Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation==
<StructureSection load='3uwo' size='340' side='right'caption='[[3uwo]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uwo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DJ:3-(1-METHYL-2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)BENZAMIDE'>0DJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwo OCA], [https://pdbe.org/3uwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwo RCSB], [https://www.ebi.ac.uk/pdbsum/3uwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).

==See Also==
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Chang J]]
[[Category: Choi JY]]
[[Category: Desbonnet CR]]
[[Category: Dillman K]]
[[Category: Miller AA]]
[[Category: Miller JR]]
[[Category: Plummer MS]]
[[Category: Roush WR]]
[[Category: Soutter HH]]
[[Category: Starr J]]