View source for 3uxg


==Crystal structure of RFXANK==
<StructureSection load='3uxg' size='340' side='right'caption='[[3uxg]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UXG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uxg OCA], [https://pdbe.org/3uxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uxg RCSB], [https://www.ebi.ac.uk/pdbsum/3uxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uxg ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9806546</ref> <ref>PMID:10072068</ref> <ref>PMID:10725724</ref> 
== Function ==
[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bian C]]
[[Category: Bountra C]]
[[Category: Chao X]]
[[Category: Edwards AM]]
[[Category: Li Y]]
[[Category: Min J]]
[[Category: Tempel W]]
[[Category: Weigelt J]]