View source for 3uxm


==Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation==
<StructureSection load='3uxm' size='340' side='right'caption='[[3uxm]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uxm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UXM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DN:5-DEOXY-5-FLUOROTHYMIDINE'>0DN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uxm OCA], [https://pdbe.org/3uxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uxm RCSB], [https://www.ebi.ac.uk/pdbsum/3uxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uxm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).

==See Also==
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Chang J]]
[[Category: Choi JY]]
[[Category: Desbonnet CR]]
[[Category: Dillman K]]
[[Category: Miller AA]]
[[Category: Miller JR]]
[[Category: Plummer MS]]
[[Category: Roush WR]]
[[Category: Soutter HH]]
[[Category: Starr J]]