View source for 3uxo


==Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme==
<StructureSection load='3uxo' size='340' side='right'caption='[[3uxo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uxo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UXO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uxo OCA], [https://pdbe.org/3uxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uxo RCSB], [https://www.ebi.ac.uk/pdbsum/3uxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uxo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPOLB_RAT DPOLB_RAT] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Gridley CL]]
[[Category: Jaeger J]]