View source for 3v30


==Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human RFXANK==
<StructureSection load='3v30' size='340' side='right'caption='[[3v30]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3v30]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V30 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v30 OCA], [https://pdbe.org/3v30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v30 RCSB], [https://www.ebi.ac.uk/pdbsum/3v30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v30 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9806546</ref> <ref>PMID:10072068</ref> <ref>PMID:10725724</ref> 
== Function ==
[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bian CB]]
[[Category: Bochkarev A]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: Kania J]]
[[Category: Lam R]]
[[Category: Min J]]
[[Category: Weigelt J]]
[[Category: Xu C]]