View source for 3vem


==Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1==
<StructureSection load='3vem' size='340' side='right'caption='[[3vem]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vem]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VEM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vem OCA], [https://pdbe.org/3vem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vem RCSB], [https://www.ebi.ac.uk/pdbsum/3vem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vem ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MOM1_ARATH MOM1_ARATH] Required for the heritable maintenance of transcriptional gene silencing (TGS) in heterochromatin, and particularly in the intermediate bivalent heterochromatin, characterized by an unsual methylation pattern consisting in hypermethylated DNA and histone H3 'Lys-4' methylation (H3K4me) together with depletion of histone H3 'Lys-9' methylation (H3K9me), in a chromatin methylation-independent manner, in a non-CG methylation context. May play a role in the RNA polymerase IV/V (Pol-IV/V)-mediated RNA-directed DNA methylation (RdDM) leading to TGS (also called siRNA-mediated TGS pathway), probably by modulating small interfering RNA (siRNA) accumulation. Especially involved in the gene silencing of the transcriptionally silent information region (TSI), 5S ribosomal RNA genes (localized in the pericentromeric heterochromatin of chromosomes 3, 4, and 5) and of 180-bp satellite repeats and 106B long terminal repeat (LTR)-like repeats of the chromocenters. Prevents the aberrant mRNA transcriptional read-through.<ref>PMID:10821279</ref> <ref>PMID:10899982</ref> <ref>PMID:12370435</ref> <ref>PMID:12609046</ref> <ref>PMID:17082821</ref> <ref>PMID:17082818</ref> <ref>PMID:18725928</ref> <ref>PMID:19910926</ref> <ref>PMID:21070421</ref> <ref>PMID:20826701</ref> <ref>PMID:20404545</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Halazonetis T]]
[[Category: Nishikura T]]
[[Category: Paszkowski J]]
[[Category: Petty TJ]]
[[Category: Thore S]]