View source for 3vis


==Crystal structure of cutinase Est119 from Thermobifida alba AHK119==
<StructureSection load='3vis' size='340' side='right'caption='[[3vis]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermobifida_alba Thermobifida alba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VIS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vis OCA], [https://pdbe.org/3vis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vis RCSB], [https://www.ebi.ac.uk/pdbsum/3vis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vis ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PETH2_THEAE PETH2_THEAE] Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle (PubMed:20393707, PubMed:22183084, PubMed:25910960, PubMed:33387709). Shows esterase activity towards p-nitrophenol-linked aliphatic esters (pNP-aliphatic esters) (PubMed:20393707, PubMed:22183084, PubMed:25910960, PubMed:33387709). Capable of degrading the plastic poly(ethylene terephthalate) (PET), the most abundant polyester plastic in the world (By similarity). Can also depolymerize the synthetic polyesters poly(epsilon-caprolactone) (PCL), poly(butylene succinate-co-adipate) (PBSA), poly(butylene succinate) (PBS), and poly(lactic acid) (PLA) (PubMed:20393707, PubMed:22183084).[UniProtKB:D4Q9N1]<ref>PMID:20393707</ref> <ref>PMID:22183084</ref> <ref>PMID:25910960</ref> <ref>PMID:33387709</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermobifida alba]]
[[Category: Karatani H]]
[[Category: Kawai F]]
[[Category: Kitadokoro K]]
[[Category: Nakamura R]]
[[Category: Nishimura K]]
[[Category: Suzuki H]]
[[Category: Thumarat U]]