View source for 3vk5


==Crystal structure of MoeO5 in complex with its product FPG==
<StructureSection load='3vk5' size='340' side='right'caption='[[3vk5]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vk5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_viridosporus_ATCC_14672 Streptomyces viridosporus ATCC 14672]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VK5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPQ:(2R)-3-(PHOSPHONOOXY)-2-{[(2Z,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIEN-1-YL]OXY}PROPANOIC+ACID'>FPQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vk5 OCA], [https://pdbe.org/3vk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vk5 RCSB], [https://www.ebi.ac.uk/pdbsum/3vk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vk5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A011_STRVD A0A011_STRVD] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
New antibiotics are needed because of the increasing occurrence of multidrug resistance, as seen in Staphylococcus aureus (MRSA). The initiating step of the biosynthesis of the next-generation drug moenomycin is catalyzed by MoeO5, which is a prenyltransferase with triose-phosphate-isomerase barrel structure as was shown by E. Oldfield, R.-T. Guo, and co-workers in their Communication (DOI:10.1002/anie.201108002). The transferred farnesyl group undergoes a trans-to-cis conversion in its first double bond.

Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes.,Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, Wang AH, Oldfield E, Guo RT Angew Chem Int Ed Engl. 2012 Mar 20. doi: 10.1002/anie.201201339. PMID:022434765<ref>PMID:022434765</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3vk5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces viridosporus ATCC 14672]]
[[Category: Guo R-T]]
[[Category: Huang C-H]]
[[Category: Ko T-P]]
[[Category: Ren F]]