View source for 3vqg


==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein==
<StructureSection load='3vqg' size='340' side='right'caption='[[3vqg]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqg OCA], [https://pdbe.org/3vqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vqg RCSB], [https://www.ebi.ac.uk/pdbsum/3vqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.  Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.

==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Akiyoshi Y]]
[[Category: Furuse M]]
[[Category: Goda N]]
[[Category: Hamada D]]
[[Category: Hiroaki H]]
[[Category: Nakagawa A]]
[[Category: Narita H]]
[[Category: Suzuki M]]
[[Category: Tenno T]]