View source for 3vqu


==CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide==
<StructureSection load='3vqu' size='340' side='right'caption='[[3vqu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vqu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=O22:4-[(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)AMINO]BENZAMIDE'>O22</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqu OCA], [https://pdbe.org/3vqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vqu RCSB], [https://www.ebi.ac.uk/pdbsum/3vqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> 

==See Also==
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Daigo Y]]
[[Category: Dohi K]]
[[Category: Endoh T]]
[[Category: Higaki M]]
[[Category: Higashino K]]
[[Category: Ide N]]
[[Category: Iguchi M]]
[[Category: Inoue M]]
[[Category: Ishioka Y]]
[[Category: Itoh T]]
[[Category: Kanazawa T]]
[[Category: Kido Y]]
[[Category: Kusakabe K]]
[[Category: Maeda M]]
[[Category: Murai H]]
[[Category: Nakamura Y]]
[[Category: Okano Y]]
[[Category: Sakamoto S]]
[[Category: Sato Y]]
[[Category: Shiota T]]
[[Category: Tachibana Y]]
[[Category: Tadano G]]
[[Category: Tagashira S]]
[[Category: Ueda K]]
[[Category: Wada T]]
[[Category: Yamamoto T]]
[[Category: Yasuo K]]