View source for 3w88


==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-200==
<StructureSection load='3w88' size='340' side='right'caption='[[3w88]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3w88]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W88 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=W88:5-[4-(6-CARBOXYNAPHTHALEN-2-YL)BUTYL]-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W88</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w88 OCA], [https://pdbe.org/3w88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w88 RCSB], [https://www.ebi.ac.uk/pdbsum/3w88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w88 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.

==See Also==
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Trypanosoma cruzi strain CL Brener]]
[[Category: Aoki T]]
[[Category: Balogun EO]]
[[Category: Harada S]]
[[Category: Hashimoto S]]
[[Category: Honma T]]
[[Category: Iida M]]
[[Category: Inaoka DK]]
[[Category: Inoue M]]
[[Category: Kita K]]
[[Category: Kuranaga T]]
[[Category: Lee N]]
[[Category: Matsuoka S]]
[[Category: Montanari CA]]
[[Category: Nara T]]
[[Category: Rocha JR]]
[[Category: Sakamoto K]]
[[Category: Shiba T]]
[[Category: Suzuki S]]
[[Category: Tabuchi T]]
[[Category: Tanaka A]]