View source for 3w93


==Crystal Structure Analysis of the synthetic GCN4 Ester coiled coil peptide==
<StructureSection load='3w93' size='340' side='right'caption='[[3w93]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3w93]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W93 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene>, <scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w93 OCA], [https://pdbe.org/3w93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w93 RCSB], [https://www.ebi.ac.uk/pdbsum/3w93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w93 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Stable and reactive: A crystal structure at 1.35 A of a thioester coiled-coil protein reveals high similarity to all-peptide-bond proteins. In these assemblies, the thioester bonds are kept reactive towards thiol molecules in the mixture. This enables efficient domain exchange between proteins in response to changes in folding conditions or introduction of external templates.

A high-resolution structure that provides insight into coiled-coil thiodepsipeptide dynamic chemistry.,Dadon Z, Samiappan M, Shahar A, Zarivach R, Ashkenasy G Angew Chem Int Ed Engl. 2013 Sep 16;52(38):9944-7. doi: 10.1002/anie.201303900., Epub 2013 Aug 8. PMID:23929823<ref>PMID:23929823</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3w93" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ashkenasy G]]
[[Category: Shahar A]]
[[Category: Zarivach R]]